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Image Search Results
Journal: Addiction (Abingdon, England)
Article Title: Effects of Sex and Alcohol Use on Antiretroviral Therapy Outcomes in Botswana: A Cohort Study
doi: 10.1111/add.13538
Figure Lengend Snippet: Relation between Exposures and Detectable HIV RNA at Month 6
Article Snippet: The primary outcome was composite treatment failure defined as death from any cause,
Techniques:
Journal: bioRxiv
Article Title: A Cultured Sensorimotor Organoid Model Forms Human Neuromuscular Junctions
doi: 10.1101/2021.03.03.433128
Figure Lengend Snippet: a, Live neuronal labeling by expression of hSYN ::EGFP delivered by an AAV9 vector. Scale bar, 100 µm. b, Quantification of neurite area as fold change of initial, from three to nine weeks in culture. Line indicates mean and shaded area indicates S.E.M.(effect of time on neurite area, n =6 organoid cultures obtained from 3 separate differentiations, linear model, F=8.743, P=1.3×10 -10 , individual comparisons: TDP-43 pair: F=37.040, P=2.0×10 -8 ; SOD1 pair: F=16.3725, P=1.0×10 -4 ; PFN1 pair: F=18.639, P=3.6×10 -5 ; interaction between time and iPSC line on neurite area, n =6 organoid cultures obtained from 3 separate differentiations, linear model, F=0.562, P=0.985). c, Normalized percentage of NMJ innervation at three months in culture (normalized to the paired isogenic controls). Bars indicates mean and S.E.M. ( n =6 organoid cultures obtained from 3 separate differentiations identified by colors, Univariate ANOVA: F=5.938, P=6.3×10 -4 ; separate two-tailed t-test; TDP-43 pair: P=0.560; SOD1 pair: P=0.010; PFN1 pair: P=0.047). d, Normalized area of the innervated NMJs at three months in culture (normalized to the paired isogenic controls). Bars indicate mean and S.E.M. ( n =6 organoid cultures obtained from 3 separate differentiations identified by colors, Univariate ANOVA: F=3.001, P=0.026; separate two-tailed t-test; TDP-43 pair: P=0.009; SOD1 pair: P=0.203; PFN1: P=0.659). e, Example of the reduction in NMJ area observed in the TDP-43 +/G298S iPSC line compared to the isogenic control. Scale bar, 100 µm.
Article Snippet: Organoid cultures were transduced with an hSYN ::
Techniques: Labeling, Expressing, Plasmid Preparation, Two Tailed Test, Control